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Background  Eukaryotic translation initiation factor  4E ‐binding protein 1 ( 4E‐BP1 ) is an important factor regulating protein translation. It also impacts proliferation, apoptosis, invasion, and the cell cycle of cancer cells. The aim of this study was to investigate the relationship between  4E‐BP1  and human immune status, recognizing immunomodulatory molecules involved in the overexpression of  4E‐BP1 .    Methods  A lentivirus expression system was used to overexpress  4E‐BP1  in the  H1299  cell line. Western blot was performed to investigate the expression level of  4E‐BP1  and  P ‐ 4E‐BP1 , and quantitative polymerase chain reaction was used to quantify gene expression of immunomodulatory molecules.    Results  The expression level of  4E‐BP1  increased significantly after lentivirus infection ( P  < 0.05). Overexpression of  4E‐BP1  upregulated the expression of interleukin ( IL) ‐1β ( P  < 0.05),  IL ‐5 ( P  < 0.001),  IL ‐23 ( P  < 0.001), macrophage inflammatory protein‐1β ( P  < 0.001), Eota‐3 ( P  < 0.05), and  MCP ‐4 ( P  < 0.05). Most of the increases were observed at the seventh day. The variation trend of  IL ‐10, cell division cycle protein 2, proliferating cell nuclear antigen, and phosphatase and tensin homolog was not clear.    Conclusion  Overexpression of  4E‐BP1  altered immune status by upregulating the expression of a series of immunomodulatory molecules, indicating that  4E‐BP1  could serve as a potential therapeutic target against cancer.

Overexpression of eukaryotic translation initiation factor 4E ‐binding protein 1 induces the alteration of immune status in H1299 lung cancer cells