Open AccessHistological subtypes of lung cancer in Chinese women from 2000 to 2012
Author(s) -
Zou Xiao g,
Lin Dongmei,
Chao Ann,
Wan Xia,
Feng Qinfu,
Li Junling,
Yang Jie,
Yang Gong Huan,
Lv Ning
Publication year - 2014
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12121
Subject(s) - medicine , lung cancer , adenocarcinoma , cancer , oncology , basal cell , carcinoma , pathology , epidemiology , gastroenterology
Abstract Background The aim of the study was to characterize the histological and epidemiological features of lung cancer in C hinese women. Methods Demographic and histological information on female lung cancer cases identified during 1 J anuary 2000 through 31 D ecember 2012 from the C ancer H ospital of the C hinese A cademy of M edical S ciences were collected. The I nternational C lassification of D iseases for O ncology system was used to classify the histological subtypes. Relative frequencies ( RF ) were estimated for major histological subtypes and compared by the years of diagnosis and birth, and among residential areas. Statistical differences were tested for RFs in the time periods with a trend test and with P earson C hi square tests for distribution. Results Of 7070 female C hinese lung cancer cases, the major histological subtypes were adenocarcinoma ( ADC ) 65.79%; squamous cell carcinoma ( SCC ) 10.21%; small cell cancer 8.12%; large cell carcinoma, 2.79%; and adeno‐squamous carcinoma ( ASC ), 2.19%. ADC increased, with RFs from 46.72% in the cases identified in 2000–2002 to 76.49% in 2011–2012 ( Z = 16.998, P < 0.0001); SCC decreased from 15.69% to 5.97% ( Z = −8.750, P < 0.0001). Compared to the cases identified in 2000–2006, the age‐adjusted RFs of ADC in 2007–2012 consistently increased in all study areas. Conclusion The significant increase of ADC of the lung in C hinese women suggests that a persistently strong exposure to potential carcinogens in the C hinese population should be further and fully investigated.