Open AccessRetrospective study of surgery versus non‐surgical management in limited‐disease small cell lung cancer
Author(s) -
Zhang Jie,
Li Shaolei,
Chen Xiaoling,
Han Jindi,
Nie Jun,
Dai Ling,
Hu Weiheng,
Tian Guangming,
Ma Xiangjuan,
Han Sen,
Wu Di,
Zheng Qingfeng,
Yang Yue,
Fang Jian
Publication year - 2014
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12109
Subject(s) - medicine , radiation therapy , retrospective cohort study , surgery , chemotherapy , proportional hazards model , multivariate analysis , stage (stratigraphy) , survival analysis , lung cancer , oncology , paleontology , biology
Background The role of surgery in limited small cell lung cancer ( SCLC ) is still controversial. To assess the role of surgery in SCLC we performed a retrospective analysis of survival in a group of limited stage patients, who were managed with trimodal therapy including surgery, or with chemotherapy and radiotherapy. Methods We performed a retrospective survival analysis in a series of 153 limited stage SCLC patients treated between 1995 and 2013. Kaplan‐ M eier survival analysis and C ox regression analysis were used to calculate the overall survival of the surgical and non‐surgical groups. Results Median survival in all patients was 21.5 months. Median survival for surgical and non‐surgical patients was 30.5 months and 16.9 months, respectively. The survival curves for the two arms are significantly different ( P < 0.01). In multivariate analysis, the benefit of surgical treatment and thoracic radiotherapy varied in a time‐dependent fashion. Conclusions Our results suggest that surgery added to chemotherapy and radiotherapy may be associated with a therapeutic benefit in limited SCLC .