Open AccessAdjuvant systemic chemotherapy with or without bevacizumab in patients with resected pulmonary metastases from colorectal cancer
Author(s) -
Turan Nedim,
Benekli Mustafa,
Dane Faysal,
Unal Olcun Umit,
Kara Hasan Volkan,
Koca Dogan,
Balvan Ozlem,
Eren Tulay,
Tastekin Didem,
Helvaci Kaan,
Berk Veli,
Demirci Umut,
Ozturk Selcuk Cemil,
Dogan Erkan,
Cetin Bulent,
Kucukoner Mehmet,
Tonyali Onder,
Tufan Gulnihal,
Oztop Ilhan,
Gumus Mahmut,
Coskun Ugur,
Uner Aytug,
Ozet Ahmet,
Buyukberber Suleyman
Publication year - 2014
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12107
Subject(s) - medicine , bevacizumab , metastasectomy , oxaliplatin , irinotecan , colorectal cancer , oncology , chemotherapy , kras , regimen , chemotherapy regimen , gastroenterology , cancer
We investigated the impact of modern chemotherapy regimens and bevacizumab following pulmonary metastasectomy ( PM ) from metastatic colorectal cancer ( CRC ). Methods A total of 122 consecutive patients who were curatively resected for pulmonary metastases of CRC in twelve oncology centers were retrospectively analysed between J anuary 2000 and A pril 2012. Results Of 122 patients, 14 did not receive any treatment following PM . The remaining 108 patients received fluoropyrimidine‐based ( n = 12), irinotecan‐based ( n = 56) and oxaliplatin‐based ( n = 40) chemotherapy combinations. Among these, 52 patients received bevacizumab ( BEV ) while 56 did not ( NoBEV ). Median recurrence‐free survival ( RFS ) was 17 months and median overall survival ( OS ) has not been reached at a median follow‐up of 25 months after PM . Three and five‐year OS rates were 66% and 53%, respectively. RFS and OS were similar, irrespective of the chemotherapy regimen or BEV use. Positive pulmonary margin, KRAS mutation status, and previous liver metastasectomy were negative independent prognostic factors for RFS , while pathologically confirmed thoracic lymph node involvement was the only negative independent prognostic for OS in multivariate analysis. Conclusions No significant RFS or OS difference was observed in respect to chemotherapy regimens with or without BEV in patients with pulmonary metastases of CRC following curative resection.