Open AccessLong‐term survival for 93 months of limited‐stage small cell lung cancer: A case report and literature review
Author(s) -
Zhong Yujie,
Zhang Qiuhong,
Deng Wenjing,
Zhang Yuping,
Ming Zongjuan,
Hou Yanli,
Niu Zequn,
Yang Shuanying
Publication year - 2014
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12088
Subject(s) - medicine , carboplatin , topotecan , radiation therapy , etoposide , regimen , prophylactic cranial irradiation , chemoradiotherapy , surgery , chemotherapy , lung cancer , cisplatin , conventional pci , myocardial infarction
A 49‐year‐old man was diagnosed with small cell lung cancer in M ay 2005. Chemotherapy was started with 60 mg/day cisplatin iv drip (from days one to three), 2 mg topotecan (TP) hydrochloride iv drip (from days one to four), and traditional Chinese medicine ( TCM) AiDi injection for anti‐tumor. After four cycles, he underwent conformal radiotherapy with 56 G y/28 fractions in O ctober 2005. In A pril 2006, a mass on the right supraclavicular area was found. Therefore, he underwent another course of radiotherapy. The fields included the right supraclavicular area and the radiation dose was 50 G y/25 fractions. After completion of chemoradiotherapy, the patient achieved complete remission. Subsequently, the patient received prophylactic cranial irradiation ( PCI ). Until A pril of 2012, he had been followed up regularly. Since the SCLC diagnosis, he had received TCM for seven years. In A pril 2012, the patient complained of coughing again. Subsequently, the patient was given five cycles of an etoposide carboplatin regimen. A computed tomography ( CT) scan was performed for review, which showed no obvious change. The patient underwent a second‐line chemotherapy irinotecan cisplatin three times. However, the symptoms and CT of this patient showed no significant improvement. We changed the chemotherapy regimen to TP (topotecan 1.2 mg iv drip, days one to five; carboplatin 100 mg iv drip, days one to five). After two TP regimens, the patient died in his sleep on 3 M arch 2013. In this case, the standardized sequential chemotherapy and radiotherapy treatment, PCI , TCM, and good compliance may have contributed to the patient's longer survival.