Open AccessCharacteristics and prognostic factors of synchronous multiple primary esophageal carcinoma: A report of 52 cases
Author(s) -
Li Mei,
Lin Zhixiong
Publication year - 2014
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12047
Subject(s) - medicine , multivariate analysis , radiation therapy , proportional hazards model , stage (stratigraphy) , cohort , oncology , univariate analysis , chemotherapy , survival analysis , retrospective cohort study , carcinoma , gastroenterology , paleontology , biology
Background To retrospectively analyze the clinical characteristics and prognostic factors of 52 cases of synchronous multiple primary esophageal carcinoma ( SMPEC ), in order to provide a reference for treatment strategy. Methods Clinical and survival data of 52 patients with SMPEC were analyzed retrospectively. The rates of overall survival ( OS ), depending on the different factors, were calculated using K aplan‐ M eier analysis. A log‐rank test was used for univariate survival analysis and C ox's proportional hazards regression model was used for multivariate survival analysis. Results Clinical and survival data of 52 patients with SMPEC , hospitalized from 1 J anuary 2003 to 31 O ctober 2011, were analyzed. Twelve patients underwent surgical resection, five received adjuvant radiotherapy and one received adjuvant radiochemotherapy. Thirty‐seven of the 40 non‐operative patients received external beam radiation therapy and 20 of them received platinum‐based chemotherapy. Another three non‐operative patients were given platinum‐based chemotherapy alone. The one, three, and five‐year OS and the median survival time ( MST ) were 65.4%, 17.3%, 7.7%, respectively, and 15.0 months for the whole cohort. Tumor length and M stage were independent prognostic factors for the whole cohort by multivariate survival analysis (P = 0.010 and 0.047, respectively). For the radiotherapy subgroup, multivariate analysis of prognostic factors identified that shorter tumor length, M0 stage, and chemotherapy were the predominant independent predictors of long‐term survival (P = 0.039, 0.022 and 0.010, respectively). Conclusions SMPEC is a relatively rare and aggressive tumor. Combined radiotherapy with chemotherapy seemed to bring a survival benefit and may be a better management choice for unresectable and non‐operative SMPEC .