Open AccessHistological types and localizations of lung cancers in patients with combined pulmonary fibrosis and emphysema
Author(s) -
Fujiwara Akahito,
Tsushima Kenji,
Sugiyama Shinya,
Yamaguchi Koichi,
Soeda Seiko,
Togashi Yuki,
Kono Yuta,
Kasagi Satoshi,
Setoguchi Yasuhiro
Publication year - 2013
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12023
Subject(s) - medicine , lung cancer , pathological , histopathology , lung , fibrosis , pulmonary fibrosis , pathology , gastroenterology , basal cell
Background Most patients with combined pulmonary fibrosis and emphysema ( CPFE ) are males, and heavy smokers. CPFE is more prevalent than fibrosis in patients with lung cancer, and patients with CPFE usually have a poor prognosis. This study reviewed the differences in the prevalence of lung cancer among patients with normal, fibrosis, emphysema and CPFE via chest computed tomography ( CT ), and the relationship between histopathology and the localizations of lung cancer. Methods Patients that were diagnosed with lung cancer confirmed by pathological examinations between 2003 and 2011 were retrospectively reviewed to obtain clinical, pathological, and radiological data. These patients were categorized into four groups based on chest CT findings: normal, fibrosis, emphysema and CPFE . Results Two hundred and seventy‐four patients with lung cancer were classified into 146 normal, 14 fibrosis, 78 emphysema, and 36 CPFE groups. Combined centriacinar and paraseptal emphysema was common in the CPFE group. The prevalence of squamous cell carcinoma in the CPFE group was significantly higher in comparison to the normal group. The rate of peripheral localization of lung cancer in the CPFE group was significantly higher in comparison to the normal, fibrosis, and emphysema groups. The prevalence of squamous cell carcinoma of peripheral areas in the CPFE group was significantly higher in the normal and emphysema groups. Conclusions CPFE patients demonstrated histopathological and radiological differences concerning the histological types and localization of lung cancers.