Open AccessMolecular mechanisms of LKB1 induced cell cycle arrest
Author(s) -
Zhong Diansheng,
Sun Linlin,
Dong Lixia
Publication year - 2013
Publication title -
thoracic cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.823
H-Index - 28
eISSN - 1759-7714
pISSN - 1759-7706
DOI - 10.1111/1759-7714.12003
Subject(s) - cell cycle , cell cycle checkpoint , kinase , suppressor , microbiology and biotechnology , serine , cell growth , cancer research , medicine , cell , cytoplasm , threonine , mechanism (biology) , protein kinase a , phosphorylation , biology , cancer , genetics , philosophy , epistemology
LKB1 is a serine/threonine protein kinase mutated in patients with P eutz‐ J eghers syndrome. Biallelic inactivation of LKB1 is present in up to 30% of cases of non‐small cell lung cancer ( NSCLC ). As a tumor suppressor, LKB1 functions in arresting the cell cycle and inhibiting cell growth. LKB1 leads to induction of p21/ WAF1 expression in a p53‐dependent mechanism, which is mediated by cytoplasmic LKB1 initiating negative regulation of cell growth or nuclear LKB1 directly involved in transcriptional regulation of p21/ WAF1 . Alternatively, p53 and p21/ WAF1 ‐independent mechanism of regulating cell cycle by LKB1 is also reported.