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A response regulator of the OmpR family is part of the regulatory network controlling the oxidative stress response of Rhodobacter sphaeroides
Author(s) -
Zhao Zhiping,
Peng Tao,
Oh JeongIl,
Glaeser Jens,
Weber Lennart,
Li Qingfeng,
Klug Gabriele
Publication year - 2019
Publication title -
environmental microbiology reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.229
H-Index - 69
ISSN - 1758-2229
DOI - 10.1111/1758-2229.12718
Subject(s) - regulon , rhodobacter sphaeroides , sigma factor , gene , microbiology and biotechnology , oxidative stress , regulator , biology , regulation of gene expression , genetics , chemistry , promoter , gene expression , biochemistry , bacteria
Summary As a free‐living bacterium Rhodobacter sphaeroides needs to respond to many environmental stresses. Oxidative stress, membrane stress or heat stress induce the ompR‐1 gene encoding a protein of the OmpR family. Overexpression of OmpR‐1 results in increased resistance to organic peroxides and diamide. Our data demonstrate that OmpR‐1 positively affects expression of several sRNAs with an established role in R. sphaeroides stress defences and negatively affects the promoter of the rpoHI gene. The RpoHI sigma factor has a main role in the activation of many stress responses. Thus OmpR‐1 has a balancing effect on the activation of the RpoHI regulon. We present a model with OmpR‐1 as part of a regulatory network controlling stress defences in R. sphaeroides .