Premium
Advances in genomics, transcriptomics and proteomics of toxin‐producing cyanobacteria
Author(s) -
D'Agostino Paul M.,
Woodhouse Jason N.,
Makower A. Katharina,
Yeung Anna C. Y.,
Ongley Sarah E.,
Micallef Melinda L.,
Moffitt Michelle C.,
Neilan Brett A.
Publication year - 2016
Publication title -
environmental microbiology reports
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.229
H-Index - 69
ISSN - 1758-2229
DOI - 10.1111/1758-2229.12366
Subject(s) - metaproteomics , biology , metagenomics , proteomics , computational biology , transcriptome , genomics , genome , proteogenomics , cyanobacteria , toxin , functional genomics , gene , genetics , bacteria , gene expression
Summary A common misconception persists that the genomes of toxic and non‐toxic cyanobacterial strains are largely conserved with the exception of the presence or absence of the genes responsible for toxin production. Implementation of ‐omics era technologies has challenged this paradigm, with comparative analyses providing increased insight into the differences between strains of the same species. The implementation of genomic, transcriptomic and proteomic approaches has revealed distinct profiles between toxin‐producing and non‐toxic strains. Further, metagenomics and metaproteomics highlight the genomic potential and functional state of toxic bloom events over time. In this review, we highlight how these technologies have shaped our understanding of the complex relationship between these molecules, their producers and the environment at large within which they persist.