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Development and validation of a Behçet's Disease Damage Index for adults with BD: An Explicit, Composite and Rated (ECR) tool
Author(s) -
Gheita Tamer A.,
Hammam Nevin,
Fawzy Samar M.,
Abd ElLatif Eiman,
ElGazzar Iman I.,
Samy Nermeen,
ElHammady Dina H.,
Abdel Noor Rasha,
ElShebini Emad,
ElNajjar Amany R.,
Eesa Nahla N.,
Salem Mohamed N.,
Ibrahim Soha E.,
ElEssawi Dina F.,
Elsaman Ahmed M.,
Senara Soha,
Fathi Hanan M.,
Sallam Rehab A.,
El Shereef Rawhya R.,
Abd Elazeem Mervat I.,
Fawzy Rasha M.,
Khalil Noha M.,
Shahin Dina,
ElSaadany Hanan M.,
ElKhalifa Marwa,
Nasef Samah I.,
Abdalla Ahmed M.,
Noshy Nermeen,
Said Emtethal A.,
Saad Ehab,
Moshrif Abdel Hafeez,
ElShanawany Amira T.,
AbdelFattah Yousra H.,
Raafat Hala A.,
Khalil Hossam M.
Publication year - 2021
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.14166
Subject(s) - vasculitis , medicine , behcet's disease , stage (stratigraphy) , behcet disease , index (typography) , systemic vasculitis , disease , surgery , paleontology , world wide web , computer science , biology
Background Behçet's disease (BD) is a chronic multisystem variable vessel vasculitis. Disease damage is irreversible and permanent. Validated tools evaluating damage are limited. Enhancements in the clinical treatment of vasculitis will take place from the development of refined and exclusive indices for individual vasculitic syndromes including BD and attempting their international validation. Objectives This aim was to develop and validate a simple BD Damage Index (BDI). Methods This was a nationwide study including 1252 BD patients. The work consisted of 3 stages. Stage 1: items generation for score content. Stage 2: items selection for the draft score was performed by an expert rheumatologist. Stage 3: the content validity of the draft score was assessed and BDI, Vasculitis Damage Index (VDI), Antineutrophil cytoplasmic antibody‐associated Vasculitis Index of Damage (AVID) and Combined Damage Assessment Index (CDAI) were calculated and compared. Results The mean age of the BD patients was 36.1 ± 9.9 years. Stages 1 and 2 resulted in a BDI instrument containing 73 items with a maximum score of 100. Stage 3, the VDI, CDAI, AVID, and BDI were 2.9 ± 2.2, 3.1 ± 2.3, 3.1 ± 2.3 and 5.1 ± 2.9, respectively. High correlations ( r = .9) between comparable damage scores assured acceptable concurrent validity. Conclusion The proposed BDI represents a new robust and potentially useful tool when dealing with BD chronic status.