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Evaluation of bone erosion in rheumatoid arthritis patients by high‐resolution peripheral quantitative computed tomography scans: Comparison between two semi‐automated programs in a three‐dimensional setting
Author(s) -
Figueiredo Camille Pinto,
Perez Mariana Ortega,
Sales Lucas Peixoto,
Caparbo Valeria de Falco,
Pereira Rosa Maria Rodrigues
Publication year - 2021
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.14157
Subject(s) - medicine , bone erosion , nuclear medicine , bland–altman plot , rheumatoid arthritis , interquartile range , quantitative computed tomography , radiology , bone density , limits of agreement , osteoporosis
Aim The aim of this study was to compare OsiriX software with the previous published Medical Image Analysis Framework (MIAF) method to assess the volume of erosion in patients with rheumatoid arthritis (RA). Methods Forty RA patients underwent high‐resolution peripheral quantitative computed tomography scans of the second and third metacarpophalangeal joints, and thirty‐four patients with any bone erosion were enrolled. Two techniques were applied to erosion evaluation: (a) semi‐automated MIAF software, and (b) semi‐automated segmentation by free open‐source Digital Imaging and Communications in Medicine viewer, OsiriX software. MIAF has been published before, but this is the first time that OsiriX has been used in this way in rheumatology. Bland & Altman plots described agreement between methods. Results Forty‐eight erosions from 34 patients were analyzed. Mean age was 40.74 ± 5.32 years and mean disease duration was 10.68 ± 4.96 years. Both methods demonstrated a strong correlation regarding erosion volume ( r = 0.96, P < 0.001). Median (interquartile range) of erosion volume was 12.14 (4.5–36.07) when MIAF was considered, and 11.80 (3.45–29.42) when the OsiriX tool was used ( P = 0.139). MIAF and OsiriX showed good agreement when the Bland & Altman plot was performed. Evaluation by MIAF took 22.69 ± 6.71 minutes, whereas OsiriX took only 2.62 ± 1.09 minutes ( P < 0.001). Conclusion The three‐dimensional segmentation of bone erosions can be done by both MIAF and OsiriX software with good agreement. However, because OsiriX is a widespread tool and faster, its method seems to be more feasible for evaluating peripheral bone damage, especially bone erosions.