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Clinical characteristics of Vietnamese patients with idiopathic inflammatory myopathies and autoantibodies to aminoacyl‐transfer RNA synthetases
Author(s) -
Phuong Thuy Nguyen Thi,
Ngoc Lan Nguyen Thi,
Rönnelid Johan,
Padyukov Leonid,
Lundberg Ingrid E.
Publication year - 2021
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.14105
Subject(s) - medicine , autoantibody , myositis , interstitial lung disease , dermatomyositis , antibody , antisynthetase syndrome , immunology , gastroenterology , lung
Abstract Objective To assess clinical phenotypes of anti‐aminoacyl‐transfer RNA synthetases (aaRS) autoantibodies in Vietnamese patients of Kinh ethnicity with idiopathic inflammatory myopathies (IIM). Methods In a cross‐sectional study 23 patients with anti‐aaRS autoantibodies were compared to 36 patients with other myositis‐specific antibodies and to 69 seronegative patients with IIM. Assessments included muscle performance, extra‐muscular involvement, and disease activity according to the International Myositis Assessment and Clinical Studies (IMACS). Sera were tested by a line immunoassay (Euroline Myositis Profile 4). Results The frequency of anti‐Jo‐1 antibodies was 56.5%, anti‐EJ antibodies 26.1%, and anti‐PL‐7 antibodies 17.4%, while anti‐PL‐12 and anti‐OJ antibodies were not present in any case. All patients with anti‐aaRS autoantibodies had signs of myositis. At time of investigation 22/23 patients had muscle weakness, 52.2% arthritis, 34.8% Raynaud's phenomenon, 73.9% fever, 14.3% mechanic's hands and 56.5% dysphagia. Interstitial lung disease was present in 52.2%, and pulmonary hypertension in 56.5%. The anti‐aaRS autoantibody positive group had higher disease activity in the domains of skin and pulmonary disease compared to the seronegative group and had lower disease activity in skeletal disease compared to the anti‐melanoma differentiation‐associated protein 5‐positive patients. The clinical presentation of antisynthetase syndrome was similar between the aaRS autoantibody specificities with the exception of more frequent pulmonary hypertension in anti‐Jo‐1 positive patients. Conclusions Different aaRS autoantibody specificities may vary between different ethnic populations for reasons that still need to be clarified. Furthermore, the high frequency of pulmonary hypertension is noteworthy but otherwise clinical manifestations associated with aaRS autoantibodies did not differ from other ethnic populations.