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Epigenetics of ankylosing spondylitis: Recent developments
Author(s) -
Yang Hui,
Chen Yuting,
Xu Wei,
Shao Ming,
Deng Jixiang,
Xu Shanshan,
Gao Xing,
Guan Shiyang,
Wang Jinian,
Xu Shengqian,
Shuai Zongwen,
Pan Faming
Publication year - 2021
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.14080
Subject(s) - ankylosing spondylitis , epigenetics , pathogenesis , medicine , genetic predisposition , microrna , dna methylation , disease , immunology , histone , spondylitis , epigenesis , bioinformatics , genetics , biology , pathology , gene , gene expression
Ankylosing spondylitis (AS) is a chronic inflammatory autoimmune disease which mainly affects the spine, sacroiliac joint and peripheral joints. To date, the exact causes and pathogenesis of AS still remain unknown. It is considered that the pathogenesis of AS is associated with genetic, infection, environment, immunity and other factors. Among them, the role of genetic factors in the pathogenesis of AS has been studied most deeply. However, over the past few years, the function of environmental predisposition and epigenetic modification in the pathogenesis of AS has received extensive attention. This paper summarizes the recent progress in the epigenetics of AS, including abnormal epigenetic modifications at AS‐associated genomic loci, such as DNA methylation, histone modification, microRNA, and so on. In summary, the findings of this review attempt to explain the role of epigenetic modification in the occurrence and development of AS. Nevertheless, there are still unknown and complicated aspects worth exploring to deepen our understanding of the pathogenesis of AS.