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Role of exosome in autoimmunity, with a particular emphasis on rheumatoid arthritis
Author(s) -
Hejrati Alireza,
Hasani Bahare,
Esmaili Mozhgan,
Bashash Davood,
Tavakolinia Naeimeh,
Zafari Parisa
Publication year - 2021
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.14021
Subject(s) - microvesicles , medicine , rheumatoid arthritis , autoimmunity , immunology , inflammation , exosome , arthritis , autoimmune disease , disease , pathogenesis , bioinformatics , microrna , immune system , antibody , genetics , biology , gene
Cell‐derived exosomes are identified as carriers of lipids, proteins, and genetic materials that participate in cell‐cell signal communication, biological process, and cell signaling. Also, their involvement has been reported in a vast array of disorders and inflammatory conditions such as autoimmune diseases. Rheumatoid arthritis (RA), a common cause of joint disorder, is an inflammation‐based disease in which the precise understanding of its pathogenesis needs to be further investigated. Also, there is only a palliative care approach for the alleviation of RA symptoms. This paper discusses the recent advances in the biology of exosomes in autoimmune disorders especially in RA, and also provides a new line of research for arthritis therapy using exosomes.