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Interleukin‐1 receptor‐associated kinase gene polymorphisms contribute to rheumatoid arthritis risk: A meta‐analysis
Author(s) -
Zhao Pingli,
Li Qihui,
Liang Renxian,
He Xiong
Publication year - 2020
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.13946
Subject(s) - medicine , rheumatoid arthritis , odds ratio , genotype , meta analysis , allele , confidence interval , polymorphism (computer science) , immunology , gastroenterology , gene , genetics , biology
Aim Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting about 1% of world population. Three polymorphisms of Interleukin‐1 receptor‐associated kinase ( IRAK1 ) gene, rs3027898, rs1059702 and rs1059703, are studied to associate with RA risk. However, the findings are inconclusive. Therefore, we performed a meta‐analysis to derive a more precise estimation of the impact of the 3 polymorphisms on RA risk. Method The strength of association between 3 polymorphisms and RA risk was assessed by calculating odds ratios (ORs) with the corresponding 95% confidence intervals (CIs). Results Overall, for rs3027898 polymorphism, no association was observed in pooled analysis, but the stratified analysis suggested that rs3027898 CA genotype was associated with a reduced risk of RA in an Asian population (heterozygous model: OR = 0.79, 95% CI = 0.66‐0.96, P = .018). Rs1059702 polymorphism was related with an increased RA risk (homozygous model: OR = 1.59, 95% CI = 1.19‐2.13, P = .002, heterozygous model: OR = 1.49, 95% CI = 1.17‐1.88, P = .001, and allele comparison model: OR = 1.35, 95% CI = 1.20‐1.53, P < .001). Moreover, rs1059703 was also associated with an increased RA risk (dominant model: OR = 1.26, 95% CI = 1.07‐1.49, P = .006), especially in Caucasian populations. Conclusion These results indicated that all 3 Interleukin‐1 receptor‐associated kinase (IRAK1) gene polymorphisms, rs3027898, rs1059702 and rs1059703 were related to RA risk.