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Psoriatic arthritis: A systematic review of non‐HLA genetic studies and important signaling pathways
Author(s) -
Chen Jingjing,
Yuan Feng,
Fan Xing,
Wang Yahua
Publication year - 2020
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.13879
Subject(s) - signal transduction , pathogenesis , medicine , psoriatic arthritis , jak stat signaling pathway , immunology , cancer research , bioinformatics , biology , arthritis , genetics , tyrosine kinase
Psoriatic arthritis (PsA) is a common, chronic inflammatory disease with complex pathogenesis. In recent years, a number of susceptibility non‐human leukocyte antigen (HLA) genes of PsA have been revealed, which also act as important factors in the pathogenesis of PsA as well as HLA genes. By searching the databases National Center for Biotechnology Information, Google and PubMed, 37 articles are included and 50 susceptibility non‐HLA genes for PsA are presented, such as IL23A , TNIP1 , TYK2 , STAT4 , IL12B , RUNX3 and TRAF3IP2 . In these non‐HLA genes, some are common genes shared with other diseases, whereas most of these susceptibility genes are related to the pathogenesis of PsA by activation or inhibition of the signaling pathways. Several signaling pathways possibly implicated in the pathogenesis of PsA are introduced in this paper, including the 2 mainly signaling pathways, IL23/Th17 signaling pathway and NF‐κB signaling pathway, and the other involved signaling pathways, such as JAK‐STAT signaling pathway and MAPK signaling pathway.