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Contribution of HLA‐B*51:01 and ‐A*26:01 to Behçet's disease and their clinical association in Thai patients
Author(s) -
Louthrenoo Worawit,
Kasita Nuntana,
Pathanapitoon Kessara,
Wangkaew Suparaporn,
Kuwata Shoji,
Nishi Ai,
Kaburaki Toshikatsu,
Tanaka Rie,
Takeuchi Fujio
Publication year - 2020
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.13785
Subject(s) - medicine , behcet's disease , human leukocyte antigen , gastroenterology , allele , statistical significance , clinical significance , disease , immunology , antigen , genetics , biology , gene
Aims To investigate susceptible human leukocyte antigen (HLA) alleles and their associations with clinical features in Thai patients with Behçet's disease (BD). Method Eighteen HLA‐A and 36 HLA‐B alleles were determined in 42 Thai BD patients and 99 healthy controls (HCs) by reverse line blot assay, and reconfirmed by MICRO SSP assay. Results The BD patients had significantly higher allele frequency (AF) of HLA‐B*51 than the HCs (13.10% vs 5.05%, P = .025). The AF of HLA‐A*26, ‐A*26:01 and ‐B*51:01 also was higher and almost reached statistical significance (5.59% vs 1.52%, P = .054, 5.95% vs 1.52%, P = .054 and 10.71% vs 4.04%, P = .051, respectively). However, the BD patients had significantly higher AF of either HLA‐A*26:01 or ‐B*51:01 (16.67% vs 5.56%, P = .005), or ‐A*26:01 or ‐B*51X (19.05% vs 6.56%, P = .003). The AF of HLA‐B*51:01 and ‐B*51X increased significantly in ‐A*26:01 non‐carrier BD patients (12.16% vs 4.17%, P = .024 and 14.86% vs 5.21%, P = .019, respectively); and that of HLA‐A*26:01 was significantly higher in ‐B*51X non‐carrier BD patients (7.58% vs 1.67%, P = .034). HLA‐B*51:01 associated significantly with the presence of posterior uveitis and visual impairment (18.18% vs 2.50%, P = .031 for both conditions). HLA‐B*51:01 was not observed in BD patients with gastrointestinal involvement or arthritis. Furthermore, the AF of HLA‐B*51:01 was significantly higher in HLA‐A*26:01 non‐carrier BD patients without arthritis (17.30% vs 0%, P = .050). Conclusion HLA‐B*51:01 was a susceptible allele for Thai BD patients, and associated with posterior uveitis and visual impairment. HLA‐A*26:01 was another susceptible allele in HLA‐B*51X non‐carrier patients. The protective effect of HLA‐B*51:01 on arthritis needs further investigation.