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Positive HLA‐B27 and sacroiliitis is not always spondyloarthritis
Author(s) -
Aslam Fawad,
Chivers Frederick Spencer,
Doshi Krupa B.,
ChangMiller April
Publication year - 2019
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.13738
Subject(s) - sacroiliitis , ankylosing spondylitis , medicine , hla b27 , osteomalacia , human leukocyte antigen , hypophosphatemia , spondylitis , sacroiliac joint , osteoporosis , spondylarthropathies , immunology , dermatology , surgery , antigen
A 36‐year‐old man was treated for several years with multiple agents for ankylosing spondylitis based on positive human leukocyte antigen‐B27 and sacroiliitis. He was also diagnosed with osteoporosis and hypophosphatemia. Over these years, from being an avid runner, he became dependent on a walker for ambulation. The lack of treatment response and the low phosphorus were clues that eventually led to a diagnosis of tumor‐induced osteomalacia. This case discusses the importance of not solely relying on genetic markers and sacroiliitis for diagnosing ankylosing spondylitis as other conditions can cause similar presentations.