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Relationship between polymorphisms in −572G/C interleukin 6 promoter gene polymorphisms (rs1800796) and risk of rheumatoid arthritis: A meta‐analysis
Author(s) -
Zhang Chunfang,
Jiao Shuang,
Li Tianyu,
Zhao Lihua,
Chen Huijun
Publication year - 2020
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.13729
Subject(s) - odds ratio , meta analysis , rheumatoid arthritis , genotype , confidence interval , medicine , allele , gene polymorphism , heterozygote advantage , genetics , gene , bioinformatics , biology
Aims This meta‐analysis was aimed to investigate the association between −572G/C interleukin (IL)‐6 gene polymorphism and occurrence risk of rheumatoid arthritis (RA). Methods Literature search was conducted in PubMed, Embase, Springer and Google Scholar up to November 2018. The pooled odds ratios (ORs) and 95% confidence interval (CI) were calculated by Revman 5.3. Results A total of six case‐control studies were included in this meta‐analysis. In the allele model (G vs C), homozygous gene model (GG vs CC), recessive gene model (GG vs GC + CC), and dominant gene model (GG + GC vs CC), the pooled estimate indicated there was significant association between −572G/C IL‐6 gene polymorphism and risk of RA. However, no significant statistical results were found in meta‐analyses of heterozygote gene models. Conclusions The −572G/C IL‐6 gene polymorphism is associated with the risk of RA. The GG genotype may be the main contributor in increasing susceptibility to RA.