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Clinical features and risk factors for gout attacks during anti‐tuberculosis treatment: A case‐control study in South Korea
Author(s) -
Ha YouJung,
Chung Sang Wan,
Lee Jae Hyun,
Kang Eun Ha,
Lee Yun Jong,
Song Yeong Wook
Publication year - 2019
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.13697
Subject(s) - medicine , gout , hyperuricemia , dyslipidemia , body mass index , tuberculosis , kidney disease , renal function , uric acid , disease , pathology
Aim This study aimed to investigate the clinical features and risk factors of gout attacks during anti‐tuberculosis (TB) treatment in South Korea. Method We investigated the clinical characteristics of 49 patients who suffered from gout attacks while taking anti‐TB medications. Among them, 25 TB patients having newly developed gout attacks without prior history of gout were set to the gout group. Seventy‐five age‐ and sex‐matched TB patients without gout attacks during anti‐TB therapy were randomly selected as the control group. The demographics, clinical features, and laboratory findings between the two groups were compared to establish risk factors of gout attack during anti‐TB treatment. Results The gout patients had a mean age of 67.7 ± 13.2 years and 39 patients (79.6%) were male. Approximately half of the patients experienced an attack within 2 months of treatment initiation. The attacks typically involved lower extremity joints (87.8%). The serum uric acid (SUA) levels were significantly elevated at 2 and 6 months after starting anti‐TB medication compared with those at baseline. In the case‐control study, the factors associated with gout attack were higher body mass index (BMI), higher pre‐treatment SUA levels, dyslipidemia, and reduced renal function. In the multivariate model, higher BMI, chronic kidney disease (CKD), and pre‐treatment hyperuricemia (SUA ≥ 6.8 mg/dL) were independent risk factors of gout attack while taking anti‐TB medication. Conclusions Patients with high BMI, CKD, and pre‐treatment hyperuricemia are at a higher risk of gout attack during TB treatment.