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Anti‐TIF1γ antibody and the expression of TIF1γ in idiopathic inflammatory myopathies
Author(s) -
Kim Young,
Song Kyu Sang,
Sohn Eun Hee,
Kang Seong Wook,
Yoo In Seol,
Shim SeungCheol,
Yoo SuJin,
Kim Jinhyun
Publication year - 2019
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.13424
Subject(s) - medicine , dermatomyositis , myositis , immunohistochemistry , antibody , autoantibody , pathology , inflammation , immunology
Objective Anti‐transcriptional intermediary factor 1 (TIF1) antibody is associated with idiopathic inflammatory myopathies (IIMs). The aim of this study was to investigate the expression of TIF1s in IIMs. Method TIF1α, β or γ expression in the skin and muscle of patients and controls was studied by immunohistochemistry. Serum myositis‐specific autoantibodies were detected by immunoblot. Results TIF1α was expressed in the skin of most dermatomyositis (DM) patients but not in the controls (80% vs 0%, P < 0.001). TIF1β was expressed in all tissues of patients and controls. TIF1γ was expressed in the muscle of DM patients compared to controls (42.1% vs 0%, P = 0.039) and associated with tubuloreticular bodies ( P = 0.003). Anti‐TIF1γ was related with TIF1γ expression in the muscle ( P = 0.042). Conclusion TIF1α expression in the skin and TIF1γ in the muscle of DM was increased compared to controls. TIF1γ expression in the muscle of IIMs was related to anti‐TIF1γ antibody.