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ORMDL 3 and its implication in inflammatory disorders
Author(s) -
Ma Xiaochun,
Long Feng,
Yun Yan,
Dang Jie,
Wei Shijun,
Zhang Qian,
Li Jinzhang,
Zhang Haizhou,
Zhang Wenlong,
Wang Zhengjun,
Liu Qiji,
Zou Chengwei
Publication year - 2018
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.13324
Subject(s) - ankylosing spondylitis , medicine , inflammation , endoplasmic reticulum , regulator , inflammatory bowel disease , unfolded protein response , gene , immunology , lipid metabolism , genetic association , bioinformatics , disease , genetics , biology , single nucleotide polymorphism , genotype , pathology
A growing body of evidence has suggested the genetic association of ORMDL 3 gene ( ORMDL Sphingolipid Biosynthesis Regulator 3 ) polymorphisms with a diverse set of inflammatory disorders that include bronchial asthma, inflammatory bowel disease, ankylosing spondylitis and atherosclerosis. Gene functional investigations have revealed the particular relevance of ORMDL 3 in endoplasmic reticulum stress, lipid metabolism and inflammatory reactions. Additionally, several reports have recently added a new dimension to our understanding of the modulation of ORMDL 3 gene expression in inflammation. This mini‐review summarizes the pertinent publications regarding the genetic association studies and mechanistic exploration of ORMDL 3 in common inflammatory disorders.
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