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Y RNA derived small RNAs in Sjögren's syndrome: Candidate biomarkers?
Author(s) -
Kabeerdoss Jayakanthan,
Sandhya Pulukool,
Danda Debashish
Publication year - 2017
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.13229
Subject(s) - rna , intron , non coding rna , rna silencing , biomarker , microrna , messenger rna , medicine , microbiology and biotechnology , computational biology , gene , biology , rna interference , genetics
Anti‐Ro and anti‐La antibodies are important in pathogenesis and diagnosis of Sjögren's syndrome ( SS ). Ro60, Ro52 and La are RNA binding proteins of Y RNA , which were discovered more than three decades ago. Significance of Y RNA is not appreciated as much as Ro and La in SS . It can be hypothesised that 5′‐Ys RNA , short fragment derived from Y RNA may be recognized by TLR 7 in pDC , which induces type I interferon signature in SS . New genomics tools, namely RNA seq, enables assay of 5′‐Ys RNA in blood. 5′‐Ys RNA has the potential to be a novel biomarker of SS .
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