Premium
Role of micro RNA ‐155 in rheumatoid arthritis
Author(s) -
Su LinChong,
Huang AnFang,
Jia Hong,
Liu Yi,
Xu WangDong
Publication year - 2017
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.13202
Subject(s) - rheumatoid arthritis , gene knockdown , arthritis , medicine , rna , messenger rna , immune system , regulator , pathogenesis , microrna , immunology , gene , biology , genetics
Micro RNA s (mi RNA s) are a recently discovered class of post‐transcriptional regulators that induce target messenger RNA degradation or translation inhibition. mi RNA ‐155 (miR‐155) is an important regulator of immune cells both in humans and mice, by which these cells play critical roles in the pathogenesis of rheumatoid arthritis ( RA ). Recent findings showed that expression of miR‐155 was elevated in RA patients and arthritis models. Moreover, miR‐155 overexpression or knockdown performed significantly in the development of arthritis. This review summarizes the recent findings with respect to miR‐155 in immune responses and the underlying mechanisms responsible for miR‐155‐related autoimmune arthritis. Hopefully the information obtained will benefit the development of novel therapeutic strategies.