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Potential biomarkers in patients with systemic sclerosis
Author(s) -
Delle Sedie Andrea,
Riente Lucrezia,
Maggiorini Lavinia,
Pratesi Federico,
Tavoni Antonio,
Migliorini Paola,
Puxeddu Ilaria
Publication year - 2018
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.13196
Subject(s) - endostatin , angiogenesis , medicine , proteases , cell adhesion molecule , pathogenesis , biomarker , angiogenin , immunology , vascular endothelial growth factor , cell adhesion , chemistry , biochemistry , enzyme , cell , vegf receptors
Aim Reduced capillary density is considered the hallmark of systemic sclerosis ( SS c) leads to tissue hypoxia, a condition that usually induces angiogenesis. The objective of our study is to investigate mediators regulating angiogenesis in SS c and to correlate their levels with serological and clinical parameters. Methods vascular endothelial growth factor, fibroblast growth factor‐2, endostatin, thrombospondin‐1 and soluble vascular cell and intracellular adhesion molecules ( sICAM ‐1 and sVCAM ‐1) were measured in sera of SS c and normal subjects by enzyme‐linked immunosorbent assay. Results Among the pro‐ and anti‐angiogenic mediators, endostatin was significantly higher in SSc than in the control subjects. Out of the proteases involved in endostatin production, elastase but not cathepsin‐L, was significantly increased in SS c patients. The soluble adhesion molecules sICAM ‐1 and sVCAM ‐1 were significantly increased and they occur in parallel. sICAM ‐1, but not sVCAM ‐1 positively correlates with the inflammatory markers C‐reactive protein ( CRP ) and erythrocyte sedimentation rate (ESR). Conclusions Endostatin, elastase and the soluble adhesion molecules ( sICAM ‐1 and sVCAM ‐1) are potentially involved in the pathogenesis of SS c. Moreover, the significant correlation observed between sICAM ‐1 and CRP and ESR indicates that sICAM ‐1 might be a useful biomarker of the inflammatory state of the disease.