Premium
Associations between systemic bone mineral density, knee cartilage defects and bone marrow lesions in patients with knee osteoarthritis
Author(s) -
Zhu Qicui,
Xu Jianhua,
Wang Kang,
Cai Jingyu,
Wu Juan,
Ren Jiale,
Zheng Shuang,
Ding Changhai
Publication year - 2018
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.13148
Subject(s) - medicine , bone mineral , osteoarthritis , cartilage , magnetic resonance imaging , knee joint , tibia , bone marrow , radiology , anatomy , surgery , pathology , osteoporosis , alternative medicine
Aim The relationship between bone mineral density ( BMD ) and osteoarthritis ( OA ) remains controversial. This study aimed to explore the cross‐sectional associations between BMD at the total body, hip and spine and joint structural abnormalities including cartilage defects and bone marrow lesions ( BML s) in patients with knee OA . Method One hundred and eight‐five subjects with symptomatic knee OA were included in this study. T2‐weighted fast spin echo magnetic resonance imaging was used to assess knee cartilage defects and BML s. Total body, hip and spine BMD were measured using dual‐energy X‐ray absorptiometry. Results After adjustment for potential confounders, total hip BMD was negatively associated with medial tibial cartilage defects, lateral femoral cartilage defects, medial tibial BML s and lateral tibial BML s. Spine and total body BMD were negatively associated with lateral femoral cartilage defects, but not with BML s. Conclusion We concluded that BMD particularly at the hip was negatively associated with knee cartilage defects and BML s.