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Cervical spine involvement risk factors in rheumatoid arthritis: a meta‐analysis
Author(s) -
Zhu Shuai,
Xu Wangdong,
Luo Yubin,
Zhao Yi,
Liu Yi
Publication year - 2017
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.13096
Subject(s) - medicine , confidence interval , rheumatoid arthritis , odds ratio , meta analysis , erythrocyte sedimentation rate , rheumatoid factor , relative risk , surgery
Aim This study aims to discuss risk factors associated with cervical spine involvement ( CSI ) in patients with rheumatoid arthritis ( RA ). Methods A literature search was performed in Medline, EMBASE, Web of Science and CBMdisc databases for potential studies published before October 2016. The clinical and laboratory data were extracted, and a meta‐analysis was performed to evaluate the risk factors for CSI in RA patients. Results Twelve studies involving a total of 2750 cases with RA and 733 CSI (26.65%) were eligible and included in this meta‐analysis. The results showed that risk factors for CSI were female (odds ratio [OR] = 1.37, 95% confidence interval [CI]: 1.079–1.74), positive rheumatoid factor (RF) (OR = 1.351, 95% CI: 1.084–1.683), long‐term corticosteroids treatment (OR = 2.208, 95% CI: 1.732–2.815), erosion in hands or feet (OR = 2.559, 95% CI: 1.985–3.299), age (weighted mean difference [WMD] = −2.464 years, 95% CI: −3.688 to −1.240), RA duration (WMD = 1.495 years, 95% CI: 0.870–2.121), erythrocyte sedimentation rate (ESR) level (standard mean difference [SMD] = 0.288, 95% CI: 0.161–0.41), C‐reactive protein (CRP) level (SMD = 0.288, 95% CI: 0.161–0.415), Disease Activity Score of 28 joints (SMD = 0.5, 95% CI: 0.303–0.697). Conclusion The significant risk factors for CSI in RA were female gender, positive RF, long‐term corticosteroids treatment, peripheral joints erosions, younger age, long RA duration, markers of higher disease activity (ESR, CRP and Disease Activity Score).