Premium
Low prevalence of knee chondrocalcinosis and its catabolic association with serum matrix metalloproteinase 3: A rural Japanese population study
Author(s) -
Chiba Daisuke,
Tsuda Eiichi,
Sasaki Eiji,
Takahashi Ippei,
Nakaji Shigeyuki,
Ishibashi Yasuyuki
Publication year - 2018
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.13067
Subject(s) - medicine , chondrocalcinosis , matrix metalloproteinase , population , osteoarthritis , pathology , environmental health , alternative medicine
Aim This study aimed to elucidate the prevalence of radiographic knee chondrocalcinosis ( CC ) and to clarify whether CC is correlated with self‐reported knee symptoms and a serum catabolic biomarker. Methods A total of 1278 volunteers participated. Plain radiographs of both knees were obtained. Identification of a linear calcification in the knee joint space was defined as CC . Patients with a Kellgren‐Lawrence grade of 2 or more were considered to have knee osteoarthritis ( OA ). Symptoms were evaluated using the Knee injury and Osteoarthritis Outcome Score ( KOOS ) Pain scale, and serum matrix metalloproteinase‐3 ( MMP ‐3) concentration was determined. Multiple regression analysis was conducted to determine whether CC was correlated with OA , the KOOS Pain scale and MMP ‐3 concentration. Results Twenty‐eight subjects were found to have CC (2.2%), and 389 had OA (30.4%). CC was correlated with OA (odds ratio: 5.797; P = 0.006). Additionally, CC was correlated with MMP ‐3 concentration (B = 11.415, β = 0.059, P = 0.014), but not with KOOS Pain scale. Conclusions The prevalence of CC was low in the Japanese population evaluated in this study. While CC was not correlated with self‐reported knee symptoms, it was positively correlated with serum MMP ‐3 concentration.