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Cholesterol metabolism in pathogenesis of osteoarthritis disease
Author(s) -
Farnaghi Saba,
Crawford Ross,
Xiao Yin,
Prasadam Indira
Publication year - 2017
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.13061
Subject(s) - medicine , osteoarthritis , pathogenesis , disease , risk factor , metabolic syndrome , bioinformatics , cholesterol , diabetes mellitus , endocrinology , pathology , alternative medicine , biology
Several lines of research indicate that osteoarthritis ( OA ) is not only a joint disorder associated with mechanical stress and aging but also a ‘metabolic syndrome’ in which several risk factors work together to contribute to disease initiation and/or development. One such metabolic risk factor could be high cholesterol levels in the body. Even though high cholesterol level is a well‐known risk factor for cardiovascular disorders, its possible role in musculoskeletal diseases, particularly OA , is not clear. The authors discuss the fundamental viewpoints on cholesterol involvement in the pathogenesis of OA , stressing the need for understanding the molecular mechanisms behind this association. This is the area of research needed to provide knowledge on how one should live to prevent OA development as well as to suggest new targets for drug therapy.