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Relevance of clinical and autoantibody profiles in systemic sclerosis among Thais
Author(s) -
Foocharoen Chingching,
Watcharenwong Piyakarn,
Netwijitpan Sittichai,
Mahakkanukrauh Ajanee,
Suwannaroj Siraphop,
Nanagara Ratanvadee
Publication year - 2017
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.13060
Subject(s) - medicine , autoantibody , thais , scleroderma (fungus) , polymyositis , clinical significance , odds ratio , systemic scleroderma , extractable nuclear antigens , cohort , gastroenterology , retrospective cohort study , antibody , immunology , anti nuclear antibody , disease , demography , inoculation , sociology
Objective Autoantibody profiles in systemic sclerosis ( SS c) and their relative clinical association vary between studies. The rate for being anti‐topoisomerase‐I ( ATA ) positive and the association with diffuse cutaneous the SS c subset (dc SS c) is higher among Thais than among Caucasians. The objective was to evaluate the relevance of clinical presentation, namely being positive for one or more autoantibodies among Thai SS c patients. Method A retrospective, cohort study was performed among SS c patients over 18 years of age at Srinagarind Hospital, Khon Kaen University, Thailand, during January 2006 to December 2013. Autoantibodies comprising 13 SS c‐specific antigens were evaluated using the EUROIMMUN AG (Lübeck, Germany) in order to define their clinical association(s). Results Two hundred and eighty‐five scleroderma patients (200 female; 85 male) were included. The majority (66.7%) were dc SS c subset. ATA was the most common antibody profile in our patients (231 cases; 81.1%), followed by anti‐Ro 52 (87 cases; 30.5%). Eleven of our patients (3.9%) were negative for all antibody profiles and 44 cases (15.4%) were negative for ATA and anti‐centromere antibody (anti‐ CENP ). Almost 40% (112 cases) were positive for at least two autoantibodies. There was an association between the presence of ATA and hand deformity (odds ratio [ OR ] 3.94; 95% CI 1.12–13.84), anti‐ CENP and hand deformity ( OR 0.20; 95% CI 0.02–0.90), anti‐Ku and scleroderma‐polymyositis overlap syndrome ( OR 6.58; 95% CI 2.16–19.39) and the absence of both ATA and anti‐ CENP with female sex ( OR 2.90; 95% CI 1.12–7.51), limited cutaneous SS c subset ( OR 2.70; 95% CI 1.30–5.55) and scleroderma‐polymyositis overlap syndrome ( OR 2.53; 95% CI 1.04–6.16). Neither ATA nor anti‐ CENP were associated with the SS c subset. Conclusions ATA and anti‐ CENP were not helpful in differentiating the SS c subset in Thai SS c patients, albeit they were good for predicting hand function. Coexisting ATA and anti‐ CENP negativity were associated with less extensive skin tightness and SS c overlap syndrome.