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Effect of omega‐3 fatty acids on disease severity in patients with psoriasis: A systematic review
Author(s) -
Upala Sikarin,
Yong Wai Chung,
Theparee Talent,
Sanguankeo Anawin
Publication year - 2017
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.13051
Subject(s) - psoriasis , medicine , psoriasis area and severity index , observational study , randomized controlled trial , erythema , dermatology , polyunsaturated fatty acid , itching , meta analysis , medline , clinical trial , fatty acid , political science , law , organic chemistry , chemistry
Abstract Aim Many randomized controlled trials have been performed on the efficacy and mechanism of action of omega‐3 polyunsaturated fatty acids (n‐3 PUFA s) on psoriasis. However, contradictory results have been obtained. This study wants to assess the effects of n‐3 PUFAs on the severity of psoriasis. Methods The Cochrane Central Register of Controlled Trials, PubMed/ MEDLINE and EMBASE were searched for all randomized controlled trials and prospective observational studies comparing the efficacy of n‐3 PUFA s versus control in adult patients with psoriasis. The primary outcome was psoriasis severity as measured by the Psoriasis Area Severity Index ( PASI ) score. Results The initial search yielded 732 articles, 720 of which were excluded. The data of the 12 remaining studies were extracted. Some studies found that n‐3 PUFA s were associated with improvements in the PASI score, erythema, scaling, itching, area involved and infiltration. However, some studies did not find reduction in scaling, erythema, area involved or thickness in the treatment group. Conclusion It is still inconclusive whether use of n‐3 PUFA s in patients with psoriasis is associated with improvements in severity of psoriasis and other outcomes.