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Arthroscopic guided synovial biopsy in rheumatology: current perspectives
Author(s) -
Wechalekar Mihir D.,
Smith Malcolm D.
Publication year - 2017
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.13020
Subject(s) - medicine , rheumatology , biopsy , synovial membrane , gold standard (test) , sampling (signal processing) , arthroscopy , pathology , intensive care medicine , surgery , arthritis , filter (signal processing) , computer science , computer vision
Synovial membrane (SM) pathology has provided valuable insights into our current understanding of immunopathological processes and treatment responses in the inflammatory arthritides. Amongst various methods of synovial biopsy, arthroscopic techniques remain the ‘gold standard’ owing to better sampling from sites of interest, particularly in patients with partially treated disease and from areas within joints that may be difficult to access using other techniques. Newer sophisticated techniques of SM membrane analyses allow assessment of differentially regulated pathways, the knowledge of which may help elucidate diagnostic and therapeutic targets in an attempt towards developing strategies for personalised medicine in the current era of targeted biologic therapies.