Premium
Prevalence of secondary Sjögren's syndrome in Indian patients with rheumatoid arthritis: a single‐center study
Author(s) -
Santosh Krishna,
Dhir Varun,
Singh Surjit,
Sood Ashwani,
Gupta Amit,
Sharma Aman,
Sharma Shefali
Publication year - 2017
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.13017
Subject(s) - medicine , rheumatoid arthritis , sss* , rheumatology , interquartile range , sicca syndrome , gastroenterology , disease
Aim To assess the prevalence of secondary Sjögren's syndrome ( sSS ) and its association with joint damage in patients with rheumatoid arthritis ( RA ) from northern India. Methods Patients included had RA , fulfilling the 1987 American College of Rheumatology criteria, with disease duration of more than 1 year. They were administered a sicca questionnaire that included six questions from subjective criteria of American European Consensus Group ( AECG ) criteria. Those who answered affirmatively to at least one question underwent Schirmer I test (ocular function) and salivary scintigraphy (salivary gland involvement). Patients with involvement of both were classified as having sSS as per AECG criteria. A damaged joint count was done using Norfolk Arthritis Register Damaged Joint Count ( NOAR ‐ DJC ). Results This study included 199 patients with RA , with mean ( SD ) age and disease duration of 44 (9.9) and 6.8 (5.5) years, respectively. The prevalence of sicca symptoms and sSS was 14.6% and 5.5%, respectively. Those having sSS had a longer (mean ± SD ) disease duration (9.2 ± 4.0, 6.8 ± 5.5 years, P = 0.07) and were significantly older in age (50.8 ± 6.8, 43.6 ± 9.9 years, P = 0.005) than those without sSS . There was no significant difference in the median (interquartile range) damaged joint count (0 (0–2), 0 (0–2), P = 0.75) .Conclusions The prevalence of sSS in northern Indian RA patients was 5.5%, and it was significantly associated with older age but not damaged joint count.