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NLRP 3 p.Q705K and CARD 8 p.C10X single nucleotide polymorphisms are not associated with susceptibility to rheumatoid arthritis: a meta‐analysis
Author(s) -
Yang Zhaowen,
Cao Jin,
Yang Qingrui,
Zhang Yuanchao,
Han Lihui
Publication year - 2017
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.13016
Subject(s) - genotype , odds ratio , medicine , meta analysis , allele , single nucleotide polymorphism , rheumatoid arthritis , genetic model , cochrane library , gastroenterology , genetics , gene , biology
Aim Genetic factors have a substantial contribution to the pathogenesis of rheumatoid arthritis ( RA ). Single nucleotide polymorphisms of NLRP3 p.Q705K and CARD 8 p.C10X are two gene mutations that have been linked to many diseases. Here we carried out a meta‐analysis to identify their association with susceptibility to RA . Method Relevant studies were identified from databases, including PubMed, Cochrane Library, EMB ase, Elsevier Science Direct, Web of Science, SpringerLink, and so on. Data extracted from selected studies were analyzed using the Version 12.0 STATA software. Pooled odds ratios ( OR s) were calculated as the effect sizes for comparisons. Results In total, six case–control studies from five articles that contained 2705 RA patients and 2711 healthy controls were included. (i) The NLRP 3 p.Q705K polymorphism in allelic model ( OR = 0.908), genotypic models ( OR 1 = 0.786; OR 2 = 0.916; OR 3 = 0.729), dominant ( OR = 0.909) and recessive models ( OR = 0.778) were not associated with the risk of RA (all P > 0.05). (ii) The CARD 8 p.C10X polymorphism in allelic model ( OR = 0.995,), genotypic models ( OR 1 = 0.997; OR 2 = 1.052; OR 3 = 0.950), dominant ( OR = 1.033) and recessive models ( OR = 0.963) were not associated with the risk of RA (all P > 0.05). (iii) When compared with combined genotype CARD 8/ NLRP 3 AA / CC , none of the other combined genotypes had significant pooled OR s (all P > 0.05). (iv) Individuals carrying at least one variant allele at each of the two loci showed no more susceptibility to RA than those carrying only wild‐type alleles at both the NLRP 3 p.Q705K and CARD 8 p.C10X loci ( OR = 1.056, P > 0.05). Conclusion NLRP 3 p.Q705K and CARD 8 p.C10X polymorphisms were not associated with the susceptibility to RA , separately or in combined forms.