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Relationship between FokI polymorphism in the vitamin D receptor gene and fibromyalgia syndrome
Author(s) -
Maraslı Erdem,
Ozdolap Senay,
Sarıkaya Selda
Publication year - 2016
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12878
Subject(s) - foki , medicine , calcitriol receptor , fibromyalgia , fibromyalgia syndrome , polymorphism (computer science) , gene , genetics , receptor , bioinformatics , allele , biology
Aim The aim of this study was to evaluate the vitamin D receptor ( VDR ) gene FokI polymorphism frequencies distribution in subjects with fibromyalgia syndrome ( FMS ) compared to healthy controls. Method Using a case‐control design, 100 female patients, who were diagnosed with FMS according to the American College of Rheumatology criteria and 100 healthy female subjects were enrolled in this study. FokI polymorphisms of the VDR gene were analyzed by restriction fragment length polymorphisms ( RFLP ) in both groups. Results No significant differences in the frequencies distribution of both genotype and alleles of the FokI polymorphism in the VDR gene were observed between the two groups. Conclusion The relationship between VDR gene FokI polymorphism and FMS , particularly in Turkish women, could not be determined in this study. However, further studies with larger patient numbers may be needed to prove a relation between VDR gene polymorphism and FMS .