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Fatigue in patients with Behçet's syndrome: relationship with quality of life, depression, anxiety, disability and disease activity
Author(s) -
Ilhan Birkan,
Can Meryem,
AlibazOner Fatma,
YilmazOner Sibel,
PolatKorkmaz Ozge,
Ozen Gulsen,
Mumcu Gonca,
Maradit Kremers Hilal,
Direskeneli Haner
Publication year - 2018
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12839
Subject(s) - hospital anxiety and depression scale , medicine , anxiety , depression (economics) , quality of life (healthcare) , physical therapy , psychiatry , nursing , economics , macroeconomics
Objectives Fatigue is a common symptom of chronic inflammatory diseases. The objective of this study was to investigate fatigue in patients with Behçet's syndrome ( BS ) and to examine the relationship between fatigue and disease activity, quality of life, anxiety and depression. Methods This is a cross‐sectional study of 123 BS patients and 71 healthy controls in Turkey. All subjects completed the Multidimensional Assessment of Fatigue ( MAF ) questionnaire, Short form‐36 ( SF ‐36), Hospital Anxiety and Depression ( HADS ) scale and Health Assessment Questionnaire ( HAQ ). Disease activity among BS patients was assessed using the Behçet Syndrome Activity Scale ( BSAS ) and the physician's global assessment ( PGA ). Results BS patients had significantly higher MAF , HADS ‐depression ( HADS ‐D) and HADS ‐anxiety ( HADS ‐A) scores than the healthy controls ( P < 0.001). Both the physical and mental components of the SF ‐36 scale were impaired in BS patients ( P = 0.0001). BS patients with active disease, depression and anxiety had significantly higher MAF scores compared to BS patients without active disease, depression and anxiety ( P = 0.0001). MAF scores showed positive correlations with HADS ‐A, HADS ‐D, HAQ scores and negative correlations with SF ‐36 mental and physical components. In regression analyses, depression, anxiety and physical dysfunction were significantly associated with fatigue, after adjusting for age, sex, SF ‐ 36 physical and mental scores, HAQ , HADS ‐A, HADS ‐D and BSAS scores ( P < 0.05). Decreases in SF ‐36 physical and mental scores were significant predictive factors for high MAF score in healthy controls ( P < 0.05). Conclusions Fatigue is common in clinically active BS patients compared with healthy controls and inactive BS patients. Depression, anxiety and physical dysfunction were significantly associated with fatigue.