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Simultaneously increased expression of micro RNA ‐155 and suppressor of cytokine signaling 1 ( SOCS 1 ) gene in the peripheral blood mononuclear cells of patients with primary Sjögren's syndrome
Author(s) -
Chen JiQing,
Zilahi Erika,
Papp Gábor,
Sipka Sándor,
Zeher Margit
Publication year - 2017
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12804
Subject(s) - suppressor of cytokine signaling 1 , peripheral blood mononuclear cell , microrna , socs3 , cytokine , gene expression , medicine , immune system , gene , immunology , mir 155 , socs2 , suppressor , cancer research , real time polymerase chain reaction , biology , genetics , in vitro
Aim The micro RNA ‐155 (miR‐155) is regarded as a central modulator of T‐cell responses and could be a potential therapeutic target for certain inflammatory diseases. In our present study we analyzed the expression rate of miR‐155 and its functionally linked gene, the suppressor gene of cytokine signaling 1 ( SOCS 1 ) in primary Sjögren's syndrome ( pSS ). Method We enrolled 23 pSS patients and 10 healthy individuals in the study. The expression of miR‐155 and SOCS 1 gene were measured by real‐time polymerase chain reaction. Results We observed the over‐expression of miR‐155 in the peripheral mononuclear cells of patients with pSS . Surprisingly, SOCS 1 gene was also over‐expressed in pSS patients. Conclusion This unanticipated phenomenon might be a laboratory characteristic of Sjögren's syndrome, and presumably a consequence of the noteworthy difference in the pSS immune system reacting with Epstein–Barr virus.