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Role of vitamin D supplementation in improving disease activity in rheumatoid arthritis: An exploratory study
Author(s) -
Chandrashekara S.,
Patted Anand
Publication year - 2017
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12770
Subject(s) - medicine , rheumatoid arthritis , rheumatism , rheumatology , vitamin d and neurology , c reactive protein , physical therapy , gastroenterology , inflammation
Aim The aim of this exploratory study is to estimate the relationship between vitamin D (vit D) deficiency and active rheumatoid arthritis ( RA ), and the role of supplementation in improving disease activity. Method A randomized recruitment, consent screening, open‐label interventional study was conducted in patients who fulfilled American College of Rheumatology/European League Against Rheumatism 2010 criteria for diagnosing RA and on stable disease‐modifying anti‐rheumatic drugs ( DMARD s) for 3 months. Serum vit D levels and Disease Activity Score of 28 joints/C‐reactive protein ( DAS 28‐ CRP ) disease activity status were estimated at the first visit. Subjects with low vit D levels and DAS 28‐ CRP > 2.6 were supplemented with vit D for 12 weeks, and were assessed for improvement in disease activity and serum vit D levels. Results One hundred and fifty RA patients of mean age 49 ± 12.1 years, mean duration of illness 78 ± 63 months, and on treatment with DMARD s for 44 ± 39 months were recruited for the study. Of these, 73 (49%) subjects were found to have DAS 28‐ CRP > 2.6 and serum vit D below 20 ng/mL. The patients received vit D supplement of 60 000 IU/week for 6 weeks, followed by 60 000 IU/month for a total duration of 3 months. Disease activity and vit D status were assessed for 59 (80.8%) patients who reported at the end of 12 weeks of treatment. Mean DAS 28‐ CRP of these patients showed a statistically significant improvement from 3.68 ± 0.93 at baseline to 3.08 ± 1.11 after supplementation ( P = 0.002). Serum vit D levels improved from 10.05 ± 5.18 to 57.21 ± 24.77 ng/mL ( P < 0.001) during the period. Conclusion Supplementation of vit D in RA patients with persisting disease activity and vit D deficiency contributed to significant improvement in disease activity within a short duration.