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Long noncoding RNA s could be potential key players in the pathophysiology of Sjögren's syndrome
Author(s) -
Sandhya Pulukool,
Joshi Kandarp,
Scaria Vinod
Publication year - 2015
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12752
Subject(s) - long non coding rna , gene , computational biology , non coding rna , microarray , rna , biology , regulation of gene expression , pathophysiology , disease , bioinformatics , gene expression , genetics , medicine , pathology , endocrinology
Long noncoding RNA s (lnc RNA s) are a recently discovered class of noncoding functional RNA s encoded by metazoan genomes. Recent studies suggest a larger regulatory role for lnc RNA s in critical biological and disease processes. Mounting evidence on the role of lnc RNA s in regulating key processes of the immune system prompted us to hypothesize the role of lnc RNA s as key regulators of the pathophysiology of Sjögren's syndrome ( SS ). We used two similar approaches based on reanalysis of microarray expression datasets and curation of lnc RNA ‐protein coding gene interactions from literature to derive support for our hypothesis. We also discuss potential caveats to our approach and suggest approaches to validate the hypothesis. Our analysis suggests the potential larger and hitherto unknown role of lnc RNA regulatory networks in modulating the expression of key genes involved in the pathogenesis of SS and thereby modulating the pathophysiology of SS .