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Aim  To compare the efficacy, tolerability and safety of celecoxib, naproxen and placebo in Asian patients with osteoarthritis ( OA ) of the knee.    Method  Patients of Asian descent with knee  OA , aged ≥ 45 years, in a flare state with a functional capacity classification of I–III, received celecoxib 200 mg once daily, naproxen 500 mg twice daily or placebo, for 6 weeks. The change in Patient's Assessment of Arthritis Pain (week 6  vs . baseline) was the primary endpoint. Secondary endpoints, including Patient's and Physician's Global Assessments of Arthritis, Western Ontario and McMaster Universities  OA  Index ( WOMAC ), use of complementary and alternative medicines, incidence of treatment‐emergent adverse events ( TEAE s) and measurements of upper gastrointestinal tolerability, were also assessed.    Results  Three hundred and sixty‐seven patients were randomized: 145 to celecoxib, 144 to naproxen and 78 to placebo. Celecoxib was as effective as naproxen in reducing  OA  pain (least squares mean change from baseline in visual analogue scale score [standard error] −37.1 [2.0] for celecoxib and −37.5 [2.0] for naproxen). Patient's and Physician's Global Assessment of Arthritis,  WOMAC  scores, Pain Satisfaction Scale and Patient Health Questionnaire‐9 showed statistically significant improvement in active treatment groups versus placebo, with the exception of naproxen  WOMAC  scores. Treatment‐related  TEAE s occurred in 19 (13%), 34 (24%) and six (8%) patients in the celecoxib, naproxen and placebo groups, respectively.    Conclusion  Celecoxib and naproxen were comparable in their effects to reduce the signs and symptoms of knee  OA  in Asian patients. Celecoxib was shown to be safe and well tolerated in this patient population.

international journal of rheumatic diseases

Efficacy and safety of nonsteroidal anti‐inflammatory drugs in Asian patients with knee osteoarthritis: summary of a randomized, placebo‐controlled study