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Neonatal lupus erythematosus: a review of 123 cases in China
Author(s) -
Li Yiqun,
Wang Qian,
Luo Yan,
Zhao Yan
Publication year - 2015
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12652
Subject(s) - medicine , asymptomatic , incidence (geometry) , pediatrics , pregnancy , dermatology , disease , china , lupus erythematosus , immunology , antibody , physics , biology , political science , law , optics , genetics
Aim To analyze the clinical features, outcomes and prognosis of neonatal lupus erythematosus ( NLE ) in China. Method We reviewed 12 NLE cases at the Peking Union Medical College Hospital and compared the data with 111 cases reported in China between 1990 and 2014. The Chinese medical journal search engines used in this study were Wanfang.data and Science China. Results No gender dominance in NLE incidence was found. Cutaneous lesions were present in more than 96% of patients, while cardiac, hematological and hepatobiliary manifestations were seen in 12.61%, 45.53% and 17.89% of cases, respectively. Congenital heart block ( CHB ) tended to be more persistent, with two cases showing CHB for 1 year and three cases persisting for 7–10 years. In this study more than 90% of mothers were anti‐Sjögren's syndrome A positive, and 65.04% were asymptomatic prior to the pregnancy. Conclusion These results indicate that clinicians, especially dermatologists, in China should improve their recognition of this disease to avoid misdiagnosis, and more attention should be paid to the follow‐up of NLE patients and their asymptomatic mothers.