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Peripheral arterial disease in patients with giant cell arteritis: a meta‐analysis
Author(s) -
Ungprasert Patompong,
Thongprayoon Charat,
Kittanamongkolchai Wonngarm,
Srivali Narat,
Cheungpasitporn Wisit
Publication year - 2016
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12631
Subject(s) - medicine , confidence interval , meta analysis , giant cell arteritis , relative risk , hazard ratio , arteritis , observational study , study heterogeneity , incidence (geometry) , cohort study , disease , vasculitis , optics , physics
Aim To investigate the association between giant cell arteritis ( GCA ) and risk of peripheral arterial disease ( PAD ). Methods We conducted a systematic review and meta‐analysis of observational cohort studies that reported relative risks, hazard ratios or standardized incidence ratios with 95% confidence comparing PAD risk in patients with GCA versus non‐ GCA subjects. Pooled risk ratios and 95% confidence intervals were calculated using a random‐effect, generic inverse variance of DerSimonian and Laird. Results Four studies with 9789 patients with GCA and 236 728 controls were identified and included in our data analysis. The pooled risk ratio of PAD among patients with GCA compared with controls was 1.88 (95% CI 1.04–3.41). The statistical heterogeneity was high with an I 2 of 89%. Conclusion Our study demonstrated a statistically significant increased risk of PAD among patients with GCA .