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Risk factors for development of systemic lupus erythematosus among J apanese females: medical history and reproductive factors
Author(s) -
Washio Masakazu,
Takahashi Hiroki,
Kobashi Gen,
Kiyohara Chikako,
Tada Yoshifumi,
Asami Toyoko,
Ide Yuichiro,
Atsumi Tatsuya,
Horiuchi Takahiko
Publication year - 2017
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12600
Subject(s) - medicine , odds ratio , logistic regression , confidence interval , blood transfusion , case control study , medical history , risk factor , family history , obstetrics
Aim The aim of the present study was to examine the influence of medical history and reproductive factors on the development of systemic lupus erythematosus ( SLE ) among J apanese females. Methods One hundred and sixty female SLE patients and 660 female volunteers were studied in a case–control study. Unconditional logistic regression was used to compute odds ratios ( OR ) and 95% confidence intervals ( CI s). Results The present study demonstrated that medical histories of operations without blood transfusion ( OR = 1.64, 95% CI = 1.10–2.44) and operations with blood transfusion ( OR = 4.44, 95% CI = 1.93–10.23) increased the risk of SLE with adjustment for age, region, smoking and alcohol drinking. Among 91 SLE patients and 284 control subjects who had the experience of married life, nulliparity ( OR = 2.29, 95% CI = 1.05–5.17), increased the risk of SLE , while the risk decreased according to the number of children (one to two vs . none, OR = 0.27, 95% CI = 0.10–0.73; three or more vs . none, OR = 0.14, 95% CI = 0.04–0.51; P for trend < 0.01). Conclusions Several factors are suggested to be associated with the development of SLE among J apanese females.