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CCL 2, CXCL 8, CXCL 9 and CXCL 10 serum levels increase with age but are not altered by treatment with hydroxychloroquine in patients with osteoarthritis of the knees
Author(s) -
Bonfante Herval de Lacerda,
Almeida Caroline de Souza,
Abramo Clarice,
Grunewald Sabrine Teixeira Ferraz,
Levy Roger Abramino,
Teixeira Henrique Couto
Publication year - 2017
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12589
Subject(s) - cxcl9 , medicine , hydroxychloroquine , chemokine , interleukin 8 , osteoarthritis , cxcl10 , ccl2 , placebo , gastroenterology , inflammation , pathology , covid-19 , disease , alternative medicine , infectious disease (medical specialty)
Aim Osteoarthritis ( OA ) is a major cause of morbidity and incapacity in the elderly. This study evaluates serum levels of the chemokines CCL 2, CXCL 8, CXCL 9, and CXCL 10 in 16 patients with primary OA of the knees, and investigates how treatment with hydroxychloroquine ( HCQ ) for 4 months affects these chemokine levels. Method Thirteen elderly patients received a placebo. Healthy control groups consisted of 10 elderly individuals (age > 60 years) with no clinical or radiological evidence of OA ( CT ‐O), and 10 young adult individuals, ( CT ‐Y group, age < 40 years). Results The CT ‐Y group presented lower levels of all chemokines studied, in comparison to the other groups. HCQ treatment did not alter the serum levels of CCL 2 ( P = 0.80), CXCL 8 ( P = 0.76), CXCL 9 ( P = 0.95) and CXCL 10 ( P = 0.74) in OA patients. Conclusion Hydroxychloroquine treatment did not alter the serum levels of CCL 2, CXCL 8, CXCL 9 or CXCL 10 in patients with OA of the knees, although increased serum levels correlated with aging for all subjects, including controls.