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Clinical and laboratory profiles of primary Sjogren's syndrome in a Chinese population: A retrospective analysis of 315 patients
Author(s) -
Li Xiaomei,
Xu Bei,
Ma Yan,
Li Xiangpei,
Cheng Qi,
Wang Ximei,
Wang Guosheng,
Qian Long,
Wei Li
Publication year - 2015
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12583
Subject(s) - medicine , pulmonary function testing , dry cough , population , gastroenterology , interstitial lung disease , airway , retrospective cohort study , lung , surgery , environmental health
Aim To assess the clinical and laboratory features of primary Sjogren's syndrome ( pSS ) in a large teaching hospital in China. Methods Three hundred and fifteen pSS patients diagnosed according to American‐European Classification Criteria and consecutively admitted to Anhui Provincial Hospital from 1 January 1999 to 30 September 2012 were retrospectively selected in this study. Results The median age was 46.8 ± 14.4 years (range 13–83 years) and the majority of patients were female (96.5%). The common clinical features at initial presentations were dry mouth (50.2%), dry eyes (31.4%) and joint pain (24.8%); 92.6% of patients had positive anti‐ SSA antibody and 49.2% patients had positive anti‐ SSB antibody. One hundred and eighteen patients underwent labial salivary gland biopsy. According to Chisholm grading criteria, grade 3 to 4 was present in 58.5% of the patients. The frequency of interstitial lung disease ( ILD ) occurred (20.9%) in the patients with systemic extraglandular manifestations. The patients with ILD were frequently associated with positive anti‐ SSA ( P = 0.005) and low levels of C3. The most common impairment of lung function was small airway function abnormalities. Sixty‐six pSS patients with ILD ( pSS ‐ ILD ) were diagnosed with high‐resolution computed tomography and treated with corticosteroids and/or immunosuppressants, in which 18 patients had improved pulmonary function. Conclusion Labial salivary gland biopsy and anti‐nuclear antibodies spectrum were important to the diagnosis of pSS . The pSS patients had high percentage of ILD , especially small airway function abnormalities. The combination of corticosteroids and immunosuppressants appears to be effective in treatment of pSS patients with ILD.