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Endothelial progenitor cell biology in ankylosing spondylitis
Author(s) -
Verma Inderjeet,
Syngle Ashit,
Krishan Pawan
Publication year - 2015
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12487
Subject(s) - ankylosing spondylitis , basdai , medicine , progenitor cell , endothelial progenitor cell , basfi , inflammation , immunology , population , endothelial stem cell , disease , flow cytometry , stem cell , gastroenterology , biology , biochemistry , microbiology and biotechnology , environmental health , psoriatic arthritis , in vitro
Aim Endothelial progenitor cells ( EPC s) are unique populations which have reparative potential in overcoming endothelial damage and reducing cardiovascular risk. Patients with ankylosing spondylitis ( AS ) have increased risk of cardiovascular morbidity and mortality. The aim of this study was to investigate the endothelial progenitor cell population in AS patients and its potential relationships with disease variables. Methods Endothelial progenitor cells were measured in peripheral blood samples from 20 AS and 20 healthy controls by flow cytometry on the basis of CD 34 and CD 133 expression. Disease activity was evaluated by using Bath Ankylosing Spondylitis Disease Activity Index ( BASDAI ). Functional ability was monitored by using Bath Ankylosing Spondylitis Functional Index ( BASFI ). Results EPC s were depleted in AS patients as compared to healthy controls ( CD 34 + / CD 133 + : 0.027 ± 0.010% vs . 0.044 ± 0.011%, P < 0.001). EPC depletions were significantly associated with disease duration ( r = −0.52, P = 0.01), BASDAI ( r = −0.45, P = 0.04) and C‐reactive protein ( r = −0.5, P = 0.01). Conclusion This is the first study to demonstrate endothelial progenitor cell depletion in AS patients. EPC depletions inversely correlate with disease duration, disease activity and inflammation, suggesting the pivotal role of inflammation in depletion of EPC s. EPC would possibly also serve as a therapeutic target for preventing cardiovascular disease in AS .