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Clinical and immunological characteristics in 552 systemic lupus erythematosus patients in a southern province of C hina
Author(s) -
Li Wengen,
Ye Zhizhong,
Yin Zhihua,
Zhang Ke
Publication year - 2017
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12480
Subject(s) - medicine , malar rash , rheumatology , rash , anti nuclear antibody , lupus nephritis , population , pericarditis , cohort , gastroenterology , anemia , serositis , dermatology , arthritis , immunology , disease , antibody , autoantibody , environmental health
Aim The purpose of this study was to gain a better understanding of systemic lupus erythematosus ( SLE ) in H akka populations. Methods We studied the demographic, clinical and laboratory characteristics in a cohort of 552 SLE patients diagnosed at the R heumatology D epartment in M ei Z hou P eople's H ospital from January 2008 to December 2012. There were 495 women and 57 men (8.7 : 1) with a mean age of 35.3 years (range 12–78 years). The mean age at disease onset and the mean disease duration were 31.8 ± 14.4 years and 3.3 ± 2.8 years, respectively. Results The most common clinical manifestations were arthritis (61.6%), followed by malar rash (52.7%), photosensitivity (22.8%), mouth ulcers (17.0%) and discoid lupus (14.7%). The prevalence was 46.7% for nephritis (by biopsy), 18.3% for pleuritis, 15.6% for pericarditis and 4.9% for neuropsychiatric manifestations. The most common hematological manifestations were anemia (63.8%), followed by leucopenia (29.0%) and thrombocytopenia (14.9%). Antinuclear antibodies were detected in 99.8% of patients, followed by anti‐double‐stranded DNA (81.3%), anti‐ SSA ( S jögren's syndrome antigen A )/ R o (58.7%), anti‐ribonucleoprotein (36.8%), anti‐ S m (35.7%), and anti‐ SSB / L a (15.0%). Anti‐cardiolipin immunoglobulin G ( I g G ) and I g M were detected in 18.3% and 14.1% of patients, respectively. Active disease and infections were the two major causes of death. Conclusion The clinical and immunological characteristics of the SLE patients in our study place our population in the middle of the spectrum between other A sian and C aucasian populations.