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Baseline serum level of matrix metalloproteinase‐3 as a biomarker of progressive joint damage in rheumatoid arthritis patients
Author(s) -
Galil Sahar Mahfouz Abdel,
ElShafey Abeer Mohamed,
Hagrass Hoda A.,
Fawzy Faten,
Sammak Ahmed El
Publication year - 2016
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12434
Subject(s) - medicine , rheumatoid arthritis , erythrocyte sedimentation rate , biomarker , rheumatoid factor , matrix metalloproteinase 3 , cartilage oligomeric matrix protein , matrix metalloproteinase , magnetic resonance imaging , gastroenterology , arthritis , cartilage , rheumatology , c reactive protein , osteoarthritis , pathology , inflammation , radiology , biochemistry , chemistry , alternative medicine , anatomy
Aim Matrix metalloproteinase‐3 ( MMP ‐3) plays a pivotal role in the destruction of bone and degradation of cartilage components in rheumatoid arthritis ( RA ). We aimed in this study to analyze the relation between baseline levels of MMP ‐3 and the progression of joint damage in RA . Methods Eighty‐one untreated RA patients with joint symptoms for <1 year were evaluated at baseline and after 12 months as regards erythrocyte sedimentation rate ( ESR ), C‐reactive protein ( CRP ), rheumatoid factor ( RF ), anti‐cyclic citrullinated peptide (anti‐ CCP ) and plain X‐ray of both hands and wrists. Baseline levels of MMP ‐3 were measured by enzyme‐linked immunosorbent assay and magnetic resonance imaging ( MRI ) of hands/wrists was performed. Disease Activity Score ( DAS 28) and Health Assessment Questionnaire ( HAQ ) were performed at baseline evaluation and after 12 months. Results The baseline MMP ‐3 levels were significantly higher in the high‐progression group compared with the low‐progression one (95.75 ± 42.84 vs . 50.45 ± 12.83, P < 0.001). There was a positive correlation between baseline levels of MMP ‐3 and MRI erosion score and other baseline clinical parameters, except for HAQ and the van der Heijde modification of the Sharp scoring system (SvdH) scores, while after 12 months, there were high positive correlations between MMP ‐3 and SvdH score, as well as all parameters except for ESR . Conclusion Serum baseline levels of MMP ‐3 are strong prognostic markers of disease activity, and act well as an early predictor of progressive joint damage in recent‐onset RA disease.