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Prevalence and associated factors of reduced bone mineral density in patients with idiopathic inflammatory myopathies
Author(s) -
So Ho,
Yip Man Lung,
Wong Andrew Kui Man
Publication year - 2016
Publication title -
international journal of rheumatic diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.795
H-Index - 41
eISSN - 1756-185X
pISSN - 1756-1841
DOI - 10.1111/1756-185x.12405
Subject(s) - medicine , osteopenia , femoral neck , osteoporosis , bone mineral , myositis , multivariate analysis , bone density , rheumatology , cumulative dose , physical therapy , gastroenterology
Aim To determine the prevalence and identify the associated factors of reduced bone mineral density ( BMD ) in patients with idiopathic inflammatory myopathies ( IIM s). Method Existing patients diagnosed to have IIM s were recruited for measurement of BMD by dual energy X‐ray absorptiometry. Demographic, clinical and treatment variables of these patients were recorded. The prevalence of osteopenia and osteoporosis were calculated. Using multivariate analysis, the independent associated factors for reduced BMD were evaluated. Results Thirty‐eight patients with IIM s completed the study with 32 (84.2%) being female. The mean age of the patients was 52.8 ± 13.0 years. Nine (23.7%) patients had osteoporosis and 18 (47.4%) had osteopenia. Multivariate analysis revealed female gender and low serum albumin levels at onset were associated with lower spinal BMD . For femoral neck, the factors associated with lower BMD were high Myositis Disease Activity Assessment Visual Analogue Scales ( MYOACT ) score and high cumulative prednisolone dose. Conclusions Reduced BMD is prevalent in patients with IIM s. Female gender, low serum albumin level at onset, high disease activity and high cumulative corticosteroid dose appeared to be the independent associated factors. Regular assessment of BMD is advisable. The use of anti‐osteoporotic and steroid‐sparing agents should be encouraged.